Evaluation of Peripapillary RNFL (Retinal Nerve Fiber Layer) in sickle cell disease
Main Article Content
Keywords
RNFL, OCT
Abstract
Aim: To evaluate peripapillary retinal nerve fiber layer thickness (RNFL) in patients with sickle cell disease by optical coherence tomography(OCT).
Method: It was a clinical, prospective study.50 Sickle cell disease (SCD) patients & 50 controls included. Glaucoma & other ocular diseases were excluded. Complete ophthalmic evaluation & OCT was done. Through which 2 groups: focal macular thinning & no macular thinning made. Peripapillary RNFL thickness was assessed.
Result: Sickle Cell patients with macular thinning had thinner mean peripapillary RNFL thickness in nasal sector compared with control eyes & in superotemporal sector compared with Sickle Cell patient eyes without macular thinning. In severe macular thinning, mean peripapillary RNFL thickness was significantly thinner than controls.
Conclusion: Sickle Cell patients without glaucoma & with focal macular thinning have thinner peripapillary RNFL than controls & those without macular thinning. Degree of RNFL thinning correlates with severity of temporal macular thinning. These patients may require different peripapillary RNFL thickness thresholds for future glaucoma evaluations.
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